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Metabolic adaptation drives weight regain1,2

Weight loss due to calorie restriction may cause the body to react by slowing the metabolism and altering appetite-regulating hormones in a process called metabolic adaptation, making long-term weight management difficult.1,2

CTA - 0.0 - Value of Losing 15%
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The value of weight loss

Obesity is associated with multiple comorbidities, some of which can be improved through weight loss3,4

CTA - 0.0 - Obesity Treatment Modules
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Obesity Treatment Modules

This interactive, expert-led series provides practical tools for clinicians dedicated to delivering excellent obesity care

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Risk Assessment Tool

This educational tool will help you determine your patients’ risk for developing certain complications.

CTA - 0.0 - Obesity and COVID-19
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Obesity and COVID-19

Patients with obesity have a higher risk for severe illness from COVID-19.5,6 In these trying times, it is critical for patients with obesity to get the weight-management care they need.

Download of clinical overview of the AACE/ACE obesity guidelines

AACE/ACE Guidelines

Access clinical practice guidelines for the management of obesity.



1. Sumithran P, Prendergast LA, Delbridge E, et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011;365(17):1597-1604.

2. Lam YY, Ravussin E. Analysis of energy metabolism in humans: a review of methodologies. Mol Metab. 2016;5(11):1057-1071.

3. Bays HE, Seger JC, Primack C, et al. Obesity algorithm 2016-2017. Presented by the Obesity Medicine Association. Accessed June 9, 2018.

4. Ryan DH, Yockey SR. Weight loss and improvement in comorbidity: Differences at 5%, 10%, 15%, and over. Curr Obes Rep. 2017;6(2):187-194.

5. Coronavirus Disease 2019 (COVID-19): People with certain medical conditions. The Centers for Disease Control and Prevention website. Updated September 11, 2020. Accessed September 18, 2020.

6. Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area [published correction appears in JAMA. 2020 May 26;323(20):2098]. JAMA. 2020;323(20):2052-2059.