Metabolic adaptation drives weight regain1,2

Weight loss due to calorie restriction may cause the body to react by slowing the metabolism and altering appetite-regulating hormones in a process called metabolic adaptation, making long-term weight management difficult.1,2

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The value of weight loss

Obesity is associated with multiple comorbidities, some of which can be improved through weight loss3,4

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Obesity treatment modules

This interactive, expert-led series provides practical tools for clinicians dedicated to delivering excellent obesity care

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Risk assessment tool

This tool can help you assess the risks weight-related comorbidities pose to your patients and plan a course of action to help alleviate these conditions through long-term weight management.

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Obesity treatment case studies

Review case studies about patients with obesity that may be similar to patients you see in your own practice.

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Download of clinical overview of the AACE/ACE obesity guidelines

AACE/ACE guidelines

Access clinical practice guidelines for the management of obesity.

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References

1. Sumithran P, Prendergast LA, Delbridge E, et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011;365(17):1597-1604.

2. Lam YY, Ravussin E. Analysis of energy metabolism in humans: a review of methodologies. Mol Metab. 2016;5(11):1057-1071.

3. Bays HE, Seger JC, Primack C, et al. Obesity algorithm 2016-2017. Presented by the Obesity Medicine Association. Accessed June 9, 2018. https://obesitymedicine.org/obesity-algorithm.

4. Ryan DH, Yockey SR. Weight loss and improvement in comorbidity: differences at 5%, 10%, 15%, and over. Curr Obes Rep. 2017;6(2):187-194.

5. Coronavirus Disease 2019 (COVID-19): People with certain medical conditions. The Centers for Disease Control and Prevention website. Updated September 11, 2020. Accessed September 18, 2020. https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html.

6. Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area.

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