Metabolic adaptation drives weight regain1,2

Weight loss due to calorie restriction may cause the body to react by slowing the metabolism and altering appetite-regulating hormones in a process called metabolic adaptation, making long-term weight management difficult.1,2

Helping hands icon

The value of weight loss

Obesity is associated with multiple comorbidities, some of which can be improved through weight loss3,4

HCP module icon

Obesity treatment modules

This interactive, expert-led series provides practical tools for clinicians dedicated to delivering excellent obesity care

Man smiling

Reframing obesity treatment

Obesity is often managed differently than other chronic diseases. In this video, Dr. Holly Lofton addresses the importance of proper diagnosis and what treatment can mean for patients.

Weight-loss profile tool, a risk assessment tool

Risk assessment tool

This tool can help you assess the risks weight-related comorbidities pose to your patients and plan a course of action to help alleviate these conditions through long-term weight management.

Use the tool
Man smiling

Obesity treatment case studies

Review case studies about patients with obesity that may be similar to patients you see in your own practice.

Download of clinical overview of the AACE/ACE obesity guidelines

AACE/ACE guidelines

Access clinical practice guidelines for the management of obesity.



1. Sumithran P, Prendergast LA, Delbridge E, et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011;365(17):1597-1604.

2. Lam YY, Ravussin E. Analysis of energy metabolism in humans: a review of methodologies. Mol Metab. 2016;5(11):1057-1071.

3. Bays HE, Seger JC, Primack C, et al. Obesity algorithm 2016-2017. Presented by the Obesity Medicine Association. Accessed June 9, 2018.

4. Ryan DH, Yockey SR. Weight loss and improvement in comorbidity: differences at 5%, 10%, 15%, and over. Curr Obes Rep. 2017;6(2):187-194.


You are now leaving the Novo Nordisk US affiliate site. Novo Nordisk is not responsible for the content of the site you are about to visit.