Obesity is a serious chronic condition associated with multiple comorbidities, but weight loss can have an impact on some complications.1,2
Obesity is associated with at least 60 comorbidities, some of which can be improved through weight loss1-4
Explore some of the weight-related complications that are associated with obesity3:
*Includes diastolic heart failure, often called HFpEF.
Even modest amounts of weight loss can improve certain comorbidities4
Obesity is a serious health risk, but studies show that weight loss can have an impact on some weight-related comorbidities. For certain conditions, greater weight loss may be associated with greater improvements.2,4
*Not true for BMI >40 kg/m2.2
†While weight loss of 5% or more may provide a clinical benefit to the signs and symptoms of osteoarthritis, no change is evident in knee MRIs or X-Rays.2
Obesity may shorten life expectancy by up to 8 years in adults aged 20 to 39 with a BMI ≥30 kg/m2 11
Calculated years of life lost in men and women with BMI of 30 to <35 kg/m2, compared to those with ideal body weight, defined as a BMI of 18.5 to <25 kg/m2. Data are based on cardiometabolic risk factors in US adults in the National Health Examinations and Nutrition Survey data from 2003 to 2010.11
Risk Assessment Tool
This tool can help you assess the risks weight-related comorbidities pose to your patients and the best course of action to help alleviate these conditions through long-term weight-management.
Obesity is caused by a range of factors
Treating obesity requires a long-term weight-management plan
1. Bays HE, McCarthy W, Christensen S, et al. Obesity algorithm 2020. Presented by the Obesity Medicine Association. https://obesitymedicine.org/obesity-algorithm. Accessed March 16, 2021.
2. Ryan DH, Yockey SR. Weight loss and improvement in comorbidity: Differences at 5%, 10%, 15%, and over. Curr Obes Rep. 2017;6(2):187-194.
3. Garvey WT, Mechanick JI, Brett EM, et al. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract. 2016;22 Suppl 3:1-203.
4. Wing RR, Lang W, Wadden TA, et al. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care. 2011;34(7):1481-1486.
5. Metabolic syndrome. Mayoclinic.org. https://www.mayoclinic.org/diseases-conditions/metabolic-syndrome/symptoms-causes/syc-20351916. Accessed November 24, 2020.
6. Divella R, Mazzocca A, Daniele A, Sabbà C, Paradiso A. Obesity, nonalcoholic fatty liver disease and adipocytokines network in promotion of cancer. Int J Biol Sci. 2019;15(3):610-616. Published 2019 Jan 1.
7. Cancers associated with overweight and obesity make up 40 percent of cancers diagnosed in the United States. Centers for Disease Control and Prevention. https://www.cdc.gov/media/releases/2017/p1003-vs-cancer-obesity.html. Accessed February 5, 2021.
8. Romero-Corral A, Caples SM, Lopez-Jimenez F, Somers VK. Interactions between obesity and obstructive sleep apnea: implications for treatment. Chest. 2010;137(3):711-719.
9. Kitzman DW, Brubaker P, Morgan T, et al. Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: A randomized clinical trial. JAMA. 2016;315(1):36-46.
10. Sam S. Obesity and polycystic ovary syndrome. Obes Manag. 2007;3(2):69-73.
11. Grover SA, Kaouache M, Rempel P, et al. Years of life lost and healthy life years lost from diabetes and cardiovascular disease in overweight and obese people: a modelling study. Lancet Diabetes Endocrinol. 2015;3(2);114-122.